Current Issue : July - September Volume : 2018 Issue Number : 3 Articles : 5 Articles
Aim. To study the differences between acute presentation-autoimmune hepatitis (A-AIH) and chronic autoimmune hepatitis (CAIH).\nMethods.Through long-termfollow-up, 80 patientswere included in our study by using the revised international autoimmune\nhepatitis group (IAIHG) score and were divided into acute and chronic groups for comparison. Results. No significant difference\nwas found in the gender, age, IAIHG score (pretreatment/posttreatment), definite diagnosis rate, extrahepatic autoimmune disease,\nonset time, or treatment before biopsy between the acute and chronic groups. In terms of clinical symptoms, A-AIH patients were\nmore prone to jaundice, anorexia, yellow urine, and detesting oil than C-AIH patients, but melena only occurred in chronic group\n(...
The development of capsule endoscopy (CE) and double balloon enteroscopy\n(DBE) has significantly enhanced the visualization of the small bowel. CE and\nDBE have proven to be the choice of investigation for the diagnosis of small\nbowel disease and is an evident indication for obscure gastrointestinal bleeding\n(OGIB). CE or DBE respectively are frequent option of professionals for\nthe diagnosis of obscure gastrointestinal bleeding. The purpose of this review\nis to provide an overview of studies focused on patients with obscure gastrointestinal\nbleeding with previous CE and/or DBE intervention. Studies\nshow that CE and DBE have similar diagnostic yields for obscure gastrointestinal\nbleeding. Although with few chances for false negative results, most researches\nshowed good concordance between CE and DBE. However due to its\nnon-invasiveness, safety, patient tolerability and ability to view the entire\nsmall bowel, CE can be recommended as a first choice of investigation. DBE,\ndespite being more invasive, is a necessary second choice, which has both\ndiagnostic and therapeutic value, although skilled endoscopist and sedation\nare required and complications like bleeding, perforation, pancreatitis etc.\nmay occur....
Purpose: To assess the feasibility and safety of laparoscopic colorectal resection\namong octogenarians. Method: All patients who underwent laparoscopic\ncolorectal resection were identified from an IRB approved, prospectively\nmaintained laparoscopy database of a single surgeon, between the years\n2004-2010. The patients were classified into two subgroups, below and above\nthe age of 80 years (octogenarians and non octogenarians). Also, an additional\ngroup of patients, age above >80 years, who underwent open colon or rectal\nresection, was identified from the departmental database, while matching for\nage, gender, ASA score, type and indication (benign or malignant) for surgery.\nThe subgroups were compared for postoperative morbidity and recovery parameters.\nResults: Seventy four patients underwent laparoscopic colorectal resection\nprocedures by a single surgeon (20 octogenarian and 54 non-octogenarian\npatients). Mean age was 85.2 vs 62.1, respectively. Colon cancer was the most\ncommon indication for surgery in both groups of octogenarians. The Conversion\nrate was comparable between non and octogenarians. Postoperative\nmorbidity rate and length of hospital stay were significantly higher after open\nprocedures as compared to laparoscopic ones, in octogenarian and non octogenarian\npatients, 50% vs 15% vs 13%, p = 0.0001, and 12.4 vs 8.9 vs 7.6 days,\np = 0.01, respectively. Conclusions: Laparoscopic colorectal resection is feasible\nand safe in octogenarians....
Background. Since circulating tumor DNA (ctDNA) offers clear advantages as a minimally invasive method for tumor monitoring\ncompared with tumor tissue, we aimed to evaluate genotyping ctDNA using a next-generation sequencing- (NGS-) based panel\nto identify the prognostic value of mutation status in metastatic colorectal cancer (mCRC) patients with primary tumor resected\nand with subsequent lines of treatment in this study. Methods. 76 mCRC patients treated in Beijing Chao-Yang Hospital from 2011\nto 2017 were enrolled. Genotyping of RAS/BRAF in tumor tissue and ctDNA was determined by ARMS PCR and with a 40-gene\npanel using NGS, respectively. Patient clinicopathologic features and RAS/BRAF gene mutation status were evaluated by survival\nanalysis for disease-free survival (DFS) and progression-free survival (PFS). Results. Among 76 patients, KRAS distributions were\nnot significantly correlated with any clinicopathologic features.Theconcordance between tumor tissue and ctDNAKRASmutation\nwas 81.25%. Mutations of RAS/BRAF had no significant impact on DFS after surgery (hazard ratio (HR), 1.205; 95% CI, 0.618 to\n2.349; ...
Aim. To speculate on the time-dependent change of FIB4 index in patients with nonalcoholic fatty liver disease (NAFLD) and its\nincrease-decrease rate per year, simply and accurately. Methods. In all 23 patients with NAFLD with the value of FIB4 index over\n1.30 at the peak, the period from the first to each examination date was calculated and this period (years) was regarded as ...
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